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Adhesion-derived condensates control component availability to regulate adhesion dynamics

ABSTRACT: Tensins are key components of integrin adhesions and play a key role in linking the actin cytoskeleton with the ECM through interaction with integrin heterodimers. While tensin 1 (TNS1) localises to both focal and fibrillar adhesions, TNS3 has been mostly associated with fibrillar adhesions. Tensins play a role in maintaining active integrin pools and adhesion reinforcement and facilitate tension-dependent focal adhesion maturation into centrally localized fibrillar adhesions. In addition, TNS1 forms functional and reversible condensates in cells in response to different extracellular stimuli that act as reservoirs of adhesion components. Here we perform proximity biotinylation proteomics (BioID) to identify proximity interactors of TNS1 and TNS3. In parallel, we focus on identifying condensation-dependent proximity interactors of TNS1 in cells with low and high TNS1 expression.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Michal Dibus

LAB HEAD: Johanna Ivaska

PROVIDER: PXD069837 | Pride | 2026-04-24

REPOSITORIES: Pride

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			Action	DRS
	230530_BirA_1.raw	Raw
	230530_BirA_2.raw	Raw
	230530_BirA_3.raw	Raw
	230530_BirA_4.raw	Raw
	230530_TNS1_C1.raw	Raw

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