Proteomic profiling of mouse tissues exposed to aircraft noise and particulate matter

ABSTRACT: The prevalence of non-communicable diseases, particularly cardiovascular disease (CVD), in urbanized and industrialized societies has necessitated intensive investigation into the complex interplay between environmental risk factors and human health. Empirical evidence demonstrates that environmental stressors such as transportation noise and air pollution do not merely act as isolated risk factors, but also affect common pathophysiological pathways, specifically through the brain-heart axis. Despite growing recognition of these mechanistic links, comprehensive molecular characterization of the tissuespecific responses to environmental stressors remain limited. This underscores the need for systems-level approaches to elucidate the proteomic signatures underlying noise- and air-pollution induced pathophysiology. In this study, we report the proteomic profiles in mouse tissues (brain, heart, liver) induced by exposure to environmental stressors, such as aircraft noise, particulate matter (PM), and combined noise+PM exposure, as part of the MARKOPOLO project (https://markersofpollution-markopolo.eu/). We performed label-free quantitative DIA-based LC–MS/MS analysis to identify proteins and pathways affected under exposure, providing insights into molecular mechanisms of environmental stress and potential biomarkers of pollution-related changes.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Brain, Lung

SUBMITTER: Bharath Nair  

LAB HEAD: Adelina Rogowska-Wrzesinska

PROVIDER: PXD070043 | Pride | 2026-10-15

REPOSITORIES: Pride