Proteomics

Dataset Information

0

Proteomic profiling of SLIP-mediated mucus barrier restoration in Agr2 KO and DSS-induced colitis


ABSTRACT: This dataset examines the proteomic mechanisms by which synthetic mucin polymers (Shear-Labile Interaction Polymers, SLIPs) restore intestinal barrier integrity and modulate inflammation in chronic and acute colitis models. In the Agr2 KO model of chronic mucus deficiency, colon and spleen proteomes were analyzed following SLIP treatment to assess molecular recovery of mucosal and systemic homeostasis. In the DSS-induced model of acute epithelial injury, distal colon proteomes were compared between SLIP-treated and untreated mice during the recovery phase. Quantitative LC–MS/MS analyses revealed that SLIPs attenuate NF-κB and interferon-driven immune cascades, restore mitochondrial and redox pathways, and promote epithelial differentiation and mucus-associated repair. Together, these datasets define the molecular outcomes of artificial mucin therapy in distinct forms of gut barrier dysfunction.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Spleen, Colon

SUBMITTER: Jessica Xhumari  

LAB HEAD: Luiz Fernando Wurdig Roesch

PROVIDER: PXD070273 | Pride | 2026-06-01

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
11C.raw Raw
11S.raw Raw
13C.raw Raw
13S.raw Raw
17C.raw Raw
Items per page:
1 - 5 of 37

Similar Datasets

2015-08-03 | E-GEOD-40670 | biostudies-arrayexpress
2022-03-07 | PXD029356 | Pride
2022-03-07 | PXD029371 | Pride
2014-07-31 | PXD000987 | Pride
2015-08-03 | GSE40670 | GEO
2008-04-06 | E-GEOD-9913 | biostudies-arrayexpress
2026-04-01 | E-MTAB-16067 | biostudies-arrayexpress
2018-01-02 | PXD007229 | Pride
2016-01-08 | E-GEOD-76658 | biostudies-arrayexpress
2013-04-01 | E-GEOD-43338 | biostudies-arrayexpress