Proteomics

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Proteomics analysis of myocardial tissue from ischemia/reperfusion (I/R) pig model treated with cardiosphere-derived cells (CDCs)

ABSTRACT: Some studies report better outcomes in cell therapy for myocardial infarction (MI) with repeated administrations. We aimed to elucidate the potential differences in terms protein expression after one or three doses of cardiosphere-derived cells (CDCs) in a porcine MI model. CDCs were isolated from swine cardiac explants, cultured in CGM, and prepared for administration. Pigs surviving a 90-minute balloon occlusion of the mid-LAD were randomly allocated to receive vehicle (CON), one (D1) or three (D3) doses of 30x106 CDCs via the infarct-related coronary artery.

INSTRUMENT(S):

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Heart

DISEASE(S): Myocardial Ischemia

SUBMITTER: Inmaculada Jorge  

LAB HEAD: Jesús Vázquez Cobos

PROVIDER: PXD070301 | Pride | 2025-12-22

REPOSITORIES: Pride

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Dataset's files

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Action DRS
CCMI_IJ_ALL.msf Msf
CCMI_IJ_ALL.raw Raw
CCMI_IJ_FR1.msf Msf
CCMI_IJ_FR1.raw Raw
CCMI_IJ_FR2.msf Msf
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Publications

Administration of Single or Repeated Doses of CDCs in a Swine Model of Reperfused Myocardial Infarction: Magnetic Resonance and Proteomics Evaluation.

de Pedro María Ángeles MÁ   Báez-Díaz Claudia C   Jorge Inmaculada I   Vázquez-Lopez Fátima F   Torrescusa-Bermejo Axiel A   Martinez-Fernandez Beatriz B   Pulido María M   López Esther E   Vázquez Jesús J   Sánchez-Margallo Francisco M FM   Crisostomo Veronica V  

International journal of molecular sciences 20251122 23

Some studies report better outcomes in cell therapy for myocardial infarction (MI) with repeated administrations. We aimed to elucidate the potential differences in terms of cardiac function and protein expression after one or three doses of cardiosphere-derived cells (CDCs) in a porcine MI model. CDCs were isolated from swine cardiac explants, cultured in cardiomyocyte growth medium (CGM), and prepared for administration. Pigs surviving a 90 min balloon occlusion of the mid-left anterior descen  ...[more]

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