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The Nicotinamide Salvage Pathway is a Unique Metabolic target in High-Risk MDS Stem Cells

ABSTRACT: High-risk myelodysplastic syndrome (HR-MDS) is an incurable malignant clonal disorder originating in hematopoietic stem and progenitor cells (HSPC). This study demonstrates that HR-MDS HSPCs have a significant upregulation of metabolic proteins required for glycolysis, citric acid cycle, and oxidative phosphorylation.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Common Myeloid Progenitor, Primary Cell

DISEASE(S): Myelodysplastic Syndrome

SUBMITTER: Alexandra Crook

LAB HEAD: Eric M. Pietras

PROVIDER: PXD070384 | Pride | 2026-07-13

REPOSITORIES: Pride

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			Action	DRS
	SPatel_4579970_Experimental_Conditions.xlsx	Xlsx
	SW_4579970_FH17_2_10409.d.zip	Other
	SW_4579970_FH18_5_10412.d.zip	Other
	SW_4579970_FH20_1_10408.d.zip	Other
	SW_4579970_FH21_6_10413.d.zip	Other

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