Whole proteome measurement to determine effects of USP7 targeting small molecules in pancreatic cancer cells (Panc89) and melanoma cells (MaMel47)

ABSTRACT: Whole Proteome measurement of pancreatic cancer cells (Panc89) or melanoma cells (MaMel47) treated with USP7 inhibitors and degrader to compare phenotypes induced by inhibition compared to degradation. We synthesized and characterized potent USP7-targeting degrader molecules (PROTACs) and compared USP7 degradation to inhibition

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Farnusch Kaschani  

LAB HEAD: Farnusch Kaschani

PROVIDER: PXD070431 | Pride | 2026-04-21

REPOSITORIES: Pride