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Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA

ABSTRACT: Our research presents a new animal model of transient ischemic attack (TIA) that mimics brief episodes without cell loss, but results in neuronal and behavioral deficits. We identified excessive microglial reactivity, driven by acute ATP release, as a key factor in post-TIA neurological deficits, which were ameliorated by inhibiting the P2Y12 receptor, a microglia-specific purinergic receptor in the brain parenchyma responsible for activity-dependent microglial cell-cell interactions. This finding suggests that modulation of microglial reactivity offers a promising strategy to prevent cognitive impairment in TIA patients, opening avenues for future research in this underexplored area.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cerebrospinal Fluid

SUBMITTER: Sebastian Kallabis

LAB HEAD: Arthur Liesz

PROVIDER: PXD070754 | Pride | 2026-04-24

REPOSITORIES: pride

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			Action	DRS
	20220830_E2_EasyLC2_CollID_BN026_50cm_SK_MS-0007_GPF_400-500.raw	Raw
	20220830_E2_EasyLC2_CollID_BN026_50cm_SK_MS-0007_GPF_500-600.raw	Raw
	20220830_E2_EasyLC2_CollID_BN026_50cm_SK_MS-0007_GPF_600-700.raw	Raw
	20220830_E2_EasyLC2_CollID_BN026_50cm_SK_MS-0007_GPF_700-800.raw	Raw
	20220830_E2_EasyLC2_CollID_BN026_50cm_SK_MS-0007_GPF_800-900.raw	Raw

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