Dataset Information

HOW(S) RNAi in Drosophila S2 sells followed by proteomics

ABSTRACT: Proteomic analysis of S2 cells subjected to RNAi with either HOW(S) specific RNAi duplex or non-specific control

INSTRUMENT(S):

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Early Embryonic Cell

SUBMITTER: Julie Aspden

LAB HEAD: Julie Aspden

PROVIDER: PXD070902 | Pride | 2026-02-09

REPOSITORIES: Pride

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			Action	DRS
	24254_Ecl01_Karl_DIA_TRAP_50cm_120min_BSK_01_01.mzML	Mzml
	24254_Ecl01_Karl_DIA_TRAP_50cm_120min_BSK_01_01.raw	Raw
	24254_Ecl01_Karl_DIA_TRAP_50cm_120min_BSK_02_01.mzML	Mzml
	24254_Ecl01_Karl_DIA_TRAP_50cm_120min_BSK_02_01.raw	Raw
	24254_Ecl01_Karl_DIA_TRAP_50cm_120min_BSK_03_01.mzML	Mzml

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Publications

Held out wings RNA binding activity in the cytoplasm during early spermatogenesis.

Agapiou Michaela M Norris Karl K Hopes Tayah T Ward Eilidh E Hobor Fruzsina F Bretman Amanda A Edwards Thomas A TA Aspden Julie L JL

Communications biology 20260112 1

Held out wings (HOW) is an RNA-binding protein essential for spermatogenesis in Drosophila melanogaster. HOW is a signal transduction and activation of RNA (STAR) protein, regulating post-transcriptional gene expression. The characteristics of RNA-binding by the conserved short cytoplasmic isoform, HOW(S), are unknown. In vivo RIP-seq identified 121 novel transcripts bound by HOW(S) in germ stem cells and spermatogonia, many with signal transduction functions. (A/G/U)CUAAC motifs were enriched i ...[more]

PMID: 41526452

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