Tuberculous meningitis alters the proteomic landscape of brain-derived extracellular vesicles toward glial activation and neuronal injury signatures

ABSTRACT: We used our young rabbit model of TB meningitis to isolate pure and intact EVs from brain tissue (i.e., brain-derived EVs). Comparative proteomic profiling was performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

INSTRUMENT(S):

ORGANISM(S): Oryctolagus Cuniculus (rabbit)

TISSUE(S): Brain

DISEASE(S): Central Nervous System Tuberculosis

SUBMITTER: Elizabeth Tucker  

LAB HEAD: Elizabeth Tucker

PROVIDER: PXD071017 | Pride | 2026-10-26

REPOSITORIES: Pride