Proteomics

Dataset Information

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Mechanistic Insights Into Postoperative Delirium Using Untargeted High-Throughput Proteomics in Elderly Patients – A Case-Control Study

ABSTRACT: This dataset is part of the European BioCog project (EU602461) and comprises perioperative plasma samples from elderly patients (≥65 years) undergoing elective surgery. Proteomic profiling was conducted in a matched case-control design to investigate molecular mechanisms of postoperative delirium (POD). Samples were collected preoperatively (T0) and on postoperative day 1 (T1).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Delirium

SUBMITTER: Anja Freiwald  

LAB HEAD: Claudia Spies

PROVIDER: PXD071265 | Pride | 2026-02-16

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20200406_Human-isoform-uniprot-proteome-3AUP000005640.fasta Fasta
20200714_TOF1_LS_009_BioCog_P6_G10.wiff.bz2 Wiff
20200714_TOF1_LS_009_BioCog_P6_G10.wiff.scan.bz2 Wiff
20200714_TOF1_LS_010_BioCog_P5_F11.wiff.bz2 Wiff
20200714_TOF1_LS_010_BioCog_P5_F11.wiff.scan.bz2 Wiff
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Publications

Mechanistic insights into postoperative delirium using untargeted high-throughput proteomics in elderly patients - a case-control study.

Lamping Mario M   Heinrich Maria M   Farztdinov Vadim V   von Haefen Clarissa C   Sreekanth Jayanth J   Mülleder Michael M   Ralser Markus M   Winterer Georg G   Spies Claudia D CD  

Scientific reports 20260205 1

Postoperative delirium (POD) in elderly patients is a serious complication after surgery with an unclear molecular pathogenesis. Perioperative untargeted high-throughput proteomic profiling may provide insights into underlying mechanistic molecular patterns and help identify patients at high risk, guiding prevention and therapy. This study is a monocentric substudy of the European BioCog project, a prospective multicentre observational study involving elderly patients aged ≥ 65 undergoing electi  ...[more]

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