Proteomics

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Deep Top-Down Proteomics Using Capillary Zone Electrophoresis-Tandem Mass Spectrometry: Identification of 5700 Proteoforms from the Escherichia coli Proteome

ABSTRACT: We present an orthogonal multidimensional separation platform that couples size exclusion chromatography (SEC) and RPLC based protein prefractionation to CZE-MS/MS for deep top-down proteomics of Escherichia coli. The platform generated high peak capacity (∼4000) for separation of intact proteins, leading to the identification of 5700 proteoforms from the Escherichia coli proteome.

INSTRUMENT(S):

ORGANISM(S): Escherichia Coli

TISSUE(S): Cell Culture

SUBMITTER: Kun Li  

LAB HEAD: Liangliang Sun

PROVIDER: PXD071282 | Pride | 2025-12-15

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Ecoli_SEC1_F1.raw Raw
Ecoli_SEC1_F1_ms2_toppic_proteoform_single.tsv Tabular
Ecoli_SEC1_F2.raw Raw
Ecoli_SEC1_F3.raw Raw
Ecoli_SEC1_F4.raw Raw
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