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A Systems-Level view of the Trypanosoma cruzi Nucleus: Proteome profiling and interaction mapping by computational prediction and XL-MS

ABSTRACT: Protein-protein interactions (PPIs) are the basis of cellular functioning. In the cell nucleus, fundamental processes such as DNA replication, transcription and repair take place through the interaction of different proteins and complexes involving mainly histone proteins. The Trypanosoma cruzi parasite is an interesting model to study these nuclear interactions, especially involving histones and their post-translational modifications (hPTMs). However, the proteins and complexes that recognize and bind to them are poorly understood. In this work, we aimed to identify the PPIs of T. cruzi nucleus

INSTRUMENT(S):

ORGANISM(S): Trypanosoma Cruzi Dm28c

DISEASE(S): Chagas Disease

SUBMITTER: Rafael de Almeida

LAB HEAD: Lyris Martins

PROVIDER: PXD071382 | Pride | 2026-05-26

REPOSITORIES: Pride

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			Action	DRS
	20211011_Lyris_59521_NF_02_1000_template_1.mgf	Mgf
	20211011_Lyris_59521_NF_02_1000_template_1.mzML	Mzml
	20211011_Lyris_59521_NF_02_1000_template_1.mzid	Mzid
	20211011_Lyris_59521_NF_02_1000_template_1.raw	Raw
	20211011_Lyris_59521_NF_02_1000_template_2.mgf	Mgf

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