BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia

ABSTRACT: This dataset profiles the proteomic effects of altering BAP1 expression in human trophoblast stem cells and trophoblast organoids. Samples from control, BAP1-overexpressing, and BAP1-knockdown conditions were analyzed by LC–MS/MS. DIA-NN–based quantification and differential analysis revealed BAP1-dependent changes affecting trophoblast differentiation, inflammatory signaling, and pathways linked to early-onset preeclampsia.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Trophoblast Cell

SUBMITTER: Sergio Navarro  

LAB HEAD: Vicente Perez-Garcia

PROVIDER: PXD071497 | Pride | 2026-03-24

REPOSITORIES: Pride