Proteomics

Dataset Information

Exploration of protein degradability enables fully endogenous MrTAC degraders

ABSTRACT: Methylarginine degrons mark proteins for degradation in lysosomes. We leveraged the machinery responsible for methylarginine degron addition to create a chemically inducible degrader named a Methyl Arginine Targeting Chimera (MrTAC). First, we evaluated the contents of isolated lysosomes following activation of the native methylarginine degron pathway. Next, we evaluated global proteome abundance in human cell culture during treatment with different MrTACs relative to control treatments.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Clinton Yu  

LAB HEAD: Lauren Veronica

PROVIDER: PXD071805 | Pride | 2026-09-14

REPOSITORIES: Pride

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20250916_MaxQuant.xlsx Xlsx
20251022_MaxQuant.xlsx Xlsx
KP_ObitrapLUMOS_20250911_03.raw Raw
KP_ObitrapLUMOS_20250911_07.raw Raw
KP_ObitrapLUMOS_20250911_09.raw Raw
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