Dataset Information
Protein interactors of 5-FU in MDA-MB-231 cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Mda-mb-231 Cell
SUBMITTER: 
Remigiusz Serwa
LAB HEAD: Dr. Abdelhalim Azzi
PROVIDER: PXD072095 | Pride | 2026-02-16
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| HA_PISA_TMT13_fr1.raw | Raw | |||
| HA_PISA_TMT13_fr1_20240309004042.raw | Raw | |||
| HA_PISA_TMT13_fr2.raw | Raw | |||
| HA_PISA_TMT13_fr2_20240309070412.raw | Raw | |||
| HA_PISA_TMT13_fr3.raw | Raw |
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Publications
The mTORC2 component SIN1 post-transcriptionally regulates TYMS levels and modulates P53 activity in response to 5-FU chemotherapy.
Cell communication and signaling : CCS 20260128 1
Transcriptional and translation control of thymidylate synthase (TYMS) is poorly understood, particularly in response to chemotherapeutic drugs such as 5-Fluorouracil (5-FU) and its derivatives. The current study addressed this gap by demonstrating a biphasic response in TYMS protein levels upon 5-FU treatment. Indeed, we observe an initial reduction within the first few hours, followed by a marked increase at 24 h. These changes occurred independently of transcriptional regulation, as TYMS mRNA ...[more]