Dataset Information

Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNPA1) Maintains Muscle Progenitor Identity by Stabilizing the Ppp1r1b-lncRNA-PRC2 Complex

ABSTRACT: The Pierce™ Magnetic RNA–Protein Pull-Down Kit (Thermo Fisher Scientific) was used to examine proteins associated with Ppp1r1b-lncRNA. The assay was performed using C2C12 cell lysates prepared from both undifferentiated and differentiated states. Full-length in vitro–transcribed Ppp1r1b-lncRNA was used as the positive probe, and in vitro–transcribed antisense Ppp1r1b-lncRNA was used as the negative control.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Myoblast, Cell Culture

SUBMITTER: Calvin Pan

LAB HEAD: Marlin Touma

PROVIDER: PXD072229 | Pride | 2026-05-25

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20210605_GN.raw	Raw
	checksum.txt	Txt
	wc_QE_061521_XueDong_DN_control.msf	Msf
	wc_QE_061521_XueDong_DN_control.mzTab	Mztab
	wc_QE_061521_XueDong_DN_control.raw	Raw

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Publications

Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) maintains muscle progenitor identity by stabilizing the Ppp1r1b-lncRNA-PRC2 complex.

Kang Xuedong X Zhao Yan Y Nelson Stanley F SF Pyle April A Lusis Aldons J AJ Touma Marlin M

Nucleic acids research 20260501 9

Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) is a multifunctional RNA-binding protein of the hnRNP family, yet its role in long non-coding RNA (lncRNA)-mediated epigenetic regulation during myogenesis remains unclear. The lncRNA Ppp1r1b-lncRNA is an established regulator of myogenesis that functions through interaction with Polycomb repressive complex 2 (PRC2) at myogenic gene promoters. Here, we investigated the role of hnRNPA1 in Ppp1r1b-lncRNA-mediated regulation of myogenesis. Fluore ...[more]

PMID: 42152677

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