Proteomics

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Identification of targetable T-cell antigens in multiple myeloma

ABSTRACT: We applied a mass spectrometry-based immunopeptidomics approach on primary multiple myeloma (MM) samples and MM cell lines, integrating whole-exome and RNA sequencing to comprehensively characterize the MM immunopeptidome and systematically search for TAAs and neoantigens.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Bone Marrow

DISEASE(S): Multiple Myeloma

SUBMITTER: Piero Giansanti  

LAB HEAD: Piero Giansanti

PROVIDER: PXD072525 | Pride | 2026-07-23

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Ecl1_0000_R0060-04_HLA_II_L_W_DIA_01.raw Raw
Ecl1_0000_R0060-04_HLA_II_L_W_DIA_02.raw Raw
Ecl1_0000_R0060-04_HLA_II_L_W_LFQ_01.raw Raw
Ecl1_0000_R0060-04_HLA_II_L_W_LFQ_01_20240701163154.raw Raw
Ecl1_0000_R0060-04_HLA_II_L_W_LFQ_02.raw Raw
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Publications

Multiple myeloma (MM) accounts for approximately 12% of all hematologic malignancies and remains incurable despite therapeutic advances. Targeting tumor-associated antigens (TAAs) and tumor-specific neoantigens presented on human leukocyte antigen (HLA) molecules by vaccination or T cell receptor (TCR)-redirected T cells offers a promising novel immunotherapeutic strategy. However, knowledge of targetable tumor antigens, especially neoantigens, is limited. We applied a mass spectrometry (MS)-bas  ...[more]

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