Dataset Information

Polianthes tuberosa L. Extract Suppresses Melanogenesis through Concurrent Inhibition of cAMP/CREB and MAPK Signaling Pathways

ABSTRACT: Ultraviolet (UV) radiation is a primary environmental stimulus for skin hyperpigmentation. Polianthes tuberosa L. (PT), rich in polyphenols and flavonoids, possesses antioxidant and anti-inflammatory properties, yet the anti-melanogenic mechanism of the PT extract (PTE) remains unexplored. Network pharmacology revealed nuclear factor erythroid-derived 2-like 2 (NFE2L2), superoxide dismutase 1 (SOD1), nuclear factor kappa B subunit 1 (NFKB1) and interleukin-6 (IL-6) as core targets. This suggests that the therapeutic mechanism of the PTE may involve the coordinated modulation of oxidative stress (via NFE2L2/SOD1) and inflammation (via NFKB1/IL-6)—two interconnected pathways that critically drive melanogenesis following UV exposure. The PTE dose-dependently inhibited UV-induced release of inflammatory cytokines and paracrine melanogenic factors in the immortalized human keratinocyte cell line. It also mitigated UV-induced collagen reduction in fibroblasts. In the mouse melanoma cell line B16F10, the PTE significantly suppressed melanogenesis and tyrosinase activity (p < 0.001). Integration of transcriptomic and proteomic data provided a complementary view of molecular regulation at both the messenger RNA and protein levels. This convergent evidence indicated that PTE acts as a concurrent inhibitor of the cyclic adenosine monophosphate (cAMP)/protein kinase A/cAMP-response element binding protein and mitogen-activated protein kinase signaling axes, as validated by quantitative polymerase chain reaction and western blot analyses. This dual inhibition led to the downregulation of microphthalmia-associated transcription factor and its downstream melanogenic enzymes. Our findings underscore the potential of PTE as a multifaceted, natural whitening agent for cosmetic applications.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Qiaozhen Li

LAB HEAD: Qiaozhen Li

PROVIDER: PXD072752 | Pride | 2026-02-16

REPOSITORIES: Pride

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			Action	DRS
	YAS202506260063-2-TES1_Slot1-77_1_2845.raw	Raw
	YAS202506260063-2-TES2_Slot1-78_1_2846.raw	Raw
	YAS202506260063-2-TES3_Slot1-79_1_2847.raw	Raw
	YAS202506260063-2-blank1_Slot1-74_1_2842.raw	Raw
	YAS202506260063-2-blank2_Slot1-75_1_2843.raw	Raw

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Polianthes tuberosa L. Extract suppresses melanogenesis through concurrent Inhibition of cAMP/CREB and MAPK signaling pathways.

Li Qiaozhen Q Zhu Hui H Jiang Teng T Hou Rubiao R Li Jinhua J Yan Xiaodong X Wang Jing J

Scientific reports 20260124 1

PMID: 41580497

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