Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Blood
SUBMITTER: 
Peter Geon Kim
LAB HEAD: Benjamin Ebert
PROVIDER: PXD072791 | Pride | 2026-03-02
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| KO1.raw | Raw | |||
| KO2.raw | Raw | |||
| KO3.raw | Raw | |||
| KO4.raw | Raw | |||
| OGlcNAc-IPMS.csv | Csv |
Items per page: 5 1 - 5 of 10 |
Publications
Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis.
Kim Peter Geon PG Hergott Christopher B CB Miller Aidan P AP Deik Amy A Boileau Meaghan M Bullock Kevin K Pierce Kerry A KA Choy Angelina H AH Shin Wesley W McConkey Marie M Loke Justin J Ryback Birgitta A BA Trinh Michael N MN Rutter Justine C JC Yue Hong H Yoon Hojong H Park Paul P Roy Burman Shourya S SS Vander Heiden Matthew G MG Fischer Eric S ES Armstrong Scott A SA Clish Clary C Ebert Benjamin L BL
Cell chemical biology 20260210
Somatic mutations in TET2 drive hyper-inflammation in clonal hematopoiesis of indeterminate potential (CHIP), but the molecular link between TET2 inactivation and myeloid immune activation remains unclear. We used in vivo genome-wide genetic perturbations enabled by ultra-diverse barcoding in primary wild-type (WT) or Tet2 knockout (KO) Cas9<sup>+</sup> hematopoietic stem-progenitor cells (HSPCs) to elucidate the basis of Tet2 KO inflammation. We uncover a metabolic circuit by which Tet2 restrai ...[more]
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