Proteomics

Dataset Information

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Retinal proteome changes mirror brain pathology and reveal synaptic and cytoskeletal dysfunction in Alzheimer’s disease


ABSTRACT: Visual dysfunction is increasingly recognized as an important feature of Alzheimer’s disease, and substantial retinal changes have been documented across multiple studies. Yet the molecular changes underlying retinal neurodegeneration and which retinal protein signatures best track cerebral pathology remain incompletely defined. Here, we performed comprehensive mass spectrometry-based proteomics on paired retinal and hippocampal tissue from the same postmortem donors (8 AD, 8 non-demented controls) to identify disease-associated molecular signatures and assess their overlap between these tissues. Using a sequential dual-extraction protocol, differentially abundant proteins (DAPs) were identified with mixed-effects modeling. Functional enrichment and cell-type mapping based on single-cell retinal reference data assessed pathway alterations and cellular distribution of disease-associated proteins.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Retina

DISEASE(S): Alzheimer's Disease

SUBMITTER: Jessica Santiago  

LAB HEAD: Malin Wennström

PROVIDER: PXD073336 | Pride | 2026-07-29

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Retinaxhippocampus_Proteomics.xlsx Xlsx
S10_Brain_Lysis_X2305_265.raw Raw
S10_Brain_Ripa_X2306_056.raw Raw
S10_RET_Lysis_X2302_054.raw Raw
S10_RET_Ripa_X2302_113.raw Raw
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