Retinal proteome changes mirror brain pathology and reveal synaptic and cytoskeletal dysfunction in Alzheimer’s disease
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ABSTRACT: Visual dysfunction is increasingly recognized as an important feature of Alzheimer’s disease, and substantial retinal changes have been documented across multiple studies. Yet the molecular changes underlying retinal neurodegeneration and which retinal protein signatures best track cerebral pathology remain incompletely defined. Here, we performed comprehensive mass spectrometry-based proteomics on paired retinal and hippocampal tissue from the same postmortem donors (8 AD, 8 non-demented controls) to identify disease-associated molecular signatures and assess their overlap between these tissues. Using a sequential dual-extraction protocol, differentially abundant proteins (DAPs) were identified with mixed-effects modeling. Functional enrichment and cell-type mapping based on single-cell retinal reference data assessed pathway alterations and cellular distribution of disease-associated proteins.
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain, Retina
DISEASE(S): Alzheimer's Disease
SUBMITTER:
Jessica Santiago
LAB HEAD: Malin Wennström
PROVIDER: PXD073336 | Pride | 2026-07-29
REPOSITORIES: Pride
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