Proteomics

Dataset Information

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HLA-DR MAPPs Assay in moDCs From 8 Donors Loaded With Infliximab

ABSTRACT: MHC-associated peptide proteomics (MAPPs) enables direct identification of peptides naturally processed and presented by APCs, providing experimental evidence for antigen processing and HLA class II presentation. In this dataset published in PMID: 41085630, an HLA-DR–focused MAPPs workflow was used on monocyte-derived dendritic cells (moDCs) from 8 donors loaded with infliximab, enabling characterization of the infliximab-derived HLA-DR T cell epitopes for this HLA donor cohort. Samples were measured using a 30 spd Evosep One LC method and MS analysis on a timsTOF-SCP in DDA-PASEF mode.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Dendritic Cell

SUBMITTER: Thomas Van Doninck  

LAB HEAD: Elise Pepermans

PROVIDER: PXD074155 | Pride | 2026-02-13

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
Chapter_Infliximab.db.peptides.csv Csv
IMXP71_IMXP01113_Infliximab_1M_HLA2_ElA_S4-A1_1_7568.d.zip Other
IMXP71_S3_IMXP01239_Infliximab_1M_HLA2_ElA_S4-A3_1_7572.d.zip Other
IMXP71_S4_IMXP01279_Infliximab_1M_HLA2_ElA_S4-A4_1_7574.d.zip Other
IMXP71_S5_IMXP01278_Infliximab_1M_HLA2_ElA_S4-A5_1_7576.d.zip Other
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Publications

MHC II MAPPs for High-Confident Immunogenicity Risk Assessment of Biotherapeutics.

Pepermans Elise E   Sauna Zuben E ZE   Pattyn Sofie S  

Methods in molecular biology (Clifton, N.J.) 20260101

Biotherapeutics can provoke unwanted immunogenicity, which can affect the safety and/or efficacy of the drug. Consequently, immunogenicity risk assessments are carried out during drug development. Further, immunogenicity is evaluated during clinical trials prior to licensure. Most therapeutic proteins are either purified from plasma or, increasingly, manufactured using recombinant DNA technology. The immune response to these protein therapies involves internalization of the protein into antigen-  ...[more]

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