Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tandem Mass Tag based quantitative proteomic analysis of colorectal cancer cell lines

ABSTRACT: Overexpression of Oxysterol-Binding Protein-Related Protein 3 (ORP3) in colorectal cancer cell lines

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: z y

LAB HEAD: Yuchen Zhong

PROVIDER: PXD074308 | Pride | 2026-04-27

REPOSITORIES: Pride

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	Sample_1.raw	Raw
	Sample_1_msms.txt	Txt
	Sample_2.raw	Raw
	Sample_2_msms.txt	Txt
	Sample_3.raw	Raw

Items per page:

1 - 5 of 13

Publications

OSBPL3 drives colorectal cancer progression via Hippo-YAP signaling and modulates MEK inhibitor sensitivity.

Zhong Yuchen Y Zheng Chaojing C Wang Zitong Z Zhang Weiyuan W Wu Hongyu H Luo Jun J Zhang Hao H Wang Chunlin C Zhang Chenkai C Hu Hanqing H Yuan Ziming Z Wang Meng M Zhang Qian Q Wang Guiyu G

Communications biology 20260307 1

Colorectal cancer progression involves dysregulated signaling pathways such as Hippo-YAP, but upstream regulators remain poorly defined. Here we demonstrate that oxysterol-binding protein-like 3 (OSBPL3) modulates Hippo-YAP signaling to drive tumor aggressiveness. Analysis of clinical specimens and experimental models shows that elevated OSBPL3 levels in colorectal cancer tissues correlate with shortened patient survival. Depleting OSBPL3 impairs cancer cell proliferation and invasion and induce ...[more]

PMID: 41794997

Similar Datasets

Proteomic profiling of colorectal adenomas

Project description:Colorectal adenomas are cancer precursor lesions of the large bowel. In these preinvasive lesions, a vast array of genomic and epigenomic changes have been detailed, but the consequence of these molecular alterations on the effectors of biological function (proteins) has not been comprehensively explored.

2014-04-03 | PXD000445 | Pride

Membrane proteomic analysis of colorectal cancer tissue

Project description:We performed shotgun proteomics of colorectal cancer tissue and premalignant lesions using iTRAQ to identify biomarker candidate proteins for colorectal cancer.

2014-04-02 | PXD000851 | Pride

Genome-wide copy number aberrations and methylation profiles in human colorectal lesions

Project description:This SuperSeries is composed of the following subset Series: GSE35476: Array CGH analysis of human colorectal tumors GSE35508: Methylated CpG island amplification (MCA) microarray analysis of human colorectal tumors Refer to individual Series

2012-08-31 | E-GEOD-35534 | biostudies-arrayexpress

Exon level expression profiling of colorectal cancer tissue samples

Project description:This SuperSeries is composed of the following subset Series: GSE24549: Exon level expression profiling of colorectal cancer tissue samples (test sample series). GSE24550: Exon level expression profiling of colorectal cancer tissue samples (validation sample series). Refer to individual Series

2011-05-19 | E-GEOD-24551 | biostudies-arrayexpress

Array CGH analysis of human colorectal tumors

Project description:The concept of the CpG island methylator phenotype (CIMP) in colorectal cancers (CRCs) is widely accepted, though the timing of its occurrence and its interaction with other genetic defects early during carcinogenesis remains largely unknown. Our aim was to uncover the molecular evolution of CIMP CRCs through integrative analysis of endoscopic, histological and molecular signatures in precancerous and malignant colorectal lesions. A total of 84 endoscopically obtained human colorectal tumor was analyzed using Agilent CGH microarray. Copy number aberration was compared with clinicopathological features and DNA methylation status.

2012-08-31 | E-GEOD-35476 | biostudies-arrayexpress

Proteomic data for tumor pericytes derived from colorectal cancer patients

Project description:This study aims to investigate differentially expressed proteins in tumor pericytes derived from colorectal cancer patients with or without liver metastasis. Tumor pericytes were isolated from tumor of colorectal cancer patients with or without liver metastasis. Then, tumor pericytes were cultured and subjected to proteomic analysis. TCAF2 was significantly increased in tumor pericytes from liver metastasis patients.

2024-01-26 | PXD033011 | Pride

Transcriptional profiling of PKH26-labeled colorectal cancer stem cells

Project description:Quiescent cancer cells responsible for tumor chemoresistance and relapse have been identified in several tumors but in colorectal cancer (CRC) they remain largely undefined. By using a proliferation-sensitive dye, we isolated and characterized a rare subpopulation of cells from colorectal tumors which, upon gene expression, proteomic and functional studies, revealed combined features of stemness, drug resistance and epithelial-to-mesenchymal transition (EMT). Altogether, this work reveals a link between cell quiescence, EMT and therapy resistance relevant for targeting drug-resistant populations in CRC.

2022-09-30 | E-MTAB-12041 | biostudies-arrayexpress

Genome-wide analysis of unbalanced chromosomal changes in colorectal carcinoma

Project description:Colorectal carcinoma (CRC) is often characterized by chromosomal instability (CIN) which has been associated with a poor prognosis. Disease-related de novo methylation often causes gene repression that may complement chromosomal losses or mutations. To compare CpG island methylation and chromosomal abnormalities in colorectal cancer, we determineded unbalanced chromosomal changes by aCGH of CRCs that were also profiled for aberrant de novo DNA methylation at 23,000 CpG islands of the human genome (Gebhard et al. 2010; and unpublished data). Refer to individual Series. This SuperSeries is composed of the following subset Series: GSE25221: CpG island methylation in colorectal cancer GSE25228: Chromosomal abnormalities in colorectal cancer

2012-11-01 | E-GEOD-25229 | biostudies-arrayexpress

Gene level expression profiling of colorectal cancer tissue samples (test sample series)

Project description:This series is part of a larger series (GSE24549) of colorectal cancer tissue samples analyzed for global gene expression. The expression measures were used to develope a gene signature for prediction of prognosis in stage II and III colorectal cancer. Gene expression profiling of colorectal cancer tissue samples for prognosis prediction.

2012-01-05 | E-GEOD-30378 | biostudies-arrayexpress

Transcription profiling of human colorectal carcinoma cell lines HCT116 and HT29 treated with 5-ASA

Project description:Transcription profiling of human colorectal carcinoma cell lines HCT116 and HT29 treated with 5-ASA

2009-11-16 | E-TABM-768 | biostudies-arrayexpress