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Quantitative proteomic profiling of ruptured and unruptured brain arteriovenous malformations

ABSTRACT: This study presents a quantitative proteomic analysis of human brain arteriovenous malformation (AVM) tissues with different rupture status. Surgically resected AVM specimens from ruptured and unruptured lesions were subjected to protein extraction, enzymatic digestion, and liquid chromatography–tandem mass spectrometry (LC-MS/MS) analysis. The dataset aims to characterize proteomic alterations associated with hemorrhagic presentation and to identify molecular pathways potentially involved in vascular instability. Raw mass spectrometry data and processed identification results are provided to facilitate data reuse and integrative multi-omics analyses.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Vessel

SUBMITTER: Wei Zhu

LAB HEAD: Wei Zhu

PROVIDER: PXD074343 | Pride | 2026-02-15

REPOSITORIES: Pride

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