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YB-1 inhibition suppresses osteosarcoma growth and reverses tumor immunosuppression

ABSTRACT: U2OS, and SaOS cells were treated with DMSO (vehicle control) or SU056 (24h). Quantitative proteomics analysis was performed on cell lysates.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Osteosarcoma Cell Line

SUBMITTER: Sharon Pitteri

LAB HEAD: Sharon Pitteri

PROVIDER: PXD074439 | Pride | 2026-06-15

REPOSITORIES: Pride

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			Action	DRS
	Arpit_Sarcoma_SU56_shotgun_TMT_111723_01.pdResult	Other
	Arpit_Sarcoma_SU56_shotgun_TMT_111723_01.raw	Raw
	Arpit_Sarcoma_SU56_shotgun_TMT_111723_02.pdResult	Other
	Arpit_Sarcoma_SU56_shotgun_TMT_111723_02.raw	Raw
	Arpit_Sarcoma_SU56_shotgun_TMT_111723_03.pdResult	Other

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Publications

YB-1 inhibition suppresses osteosarcoma growth and reverses tumor immunosuppression.

Malhotra Sanjay V SV Stefan Kirsten K Lee Jee Min JM Tailor Dhanir D Dheeraj Arpit A Rolig Annah S AS Khou Sokchea S Grau Benedikt W BW Garcia-Marques Fernando J FJ Bermudez Abel A Davis Lara E LE Pitteri Sharon J SJ

Molecular cancer therapeutics 20260429

Osteosarcoma (OS), the most common primary bone malignancy in adolescents and young adults, is still marked by poor long-term survival and poor mortality. Although immune checkpoint blockade (ICB) has transformed treatment for several cancers, its benefit in OS has been minimal, largely due to OS's "immune-cold" phenotype characterized by scarce tumor-infiltrating lymphocytes. Novel strategies are urgently needed to overcome this resistance. Y-box binding protein 1 (YB-1), a pro-oncogenic member ...[more]

PMID: 42051192

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