Dataset Information
Global analysis of cancer cell responses to USP9X inhibition
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Philipp Schenk
LAB HEAD: David Komander
PROVIDER: PXD074729 | Pride | 2026-04-09
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| OriginalGlobal.zip | Other | |||
| checksum.txt | Txt | |||
| report.pg_matrix.tsv | Tabular |
Items per page: 1 - 3 of 3 |
Publications
Global analysis of cancer cell responses to USP9X inhibition.
The EMBO journal 20260407 9
The ubiquitin-specific protease (USP) USP9X is a human deubiquitinase (DUB) with a large number of described targets and cellular roles. In cancer, USP9X is found as an oncogene or as a tumour suppressor depending on context, and its utility as a target for cancer therapy remains unclear. We here describe WEHI-092, a piperazine-based USP9X-specific small-molecule inhibitor, which binds to a unique region in the USP9X Fingers-subdomain, distinct from known DUB-inhibitor binding sites. Using prote ...[more]
