Myeloid cell recruitment propels right ventricular dysfunction in HFpEF via sterile inflammation

ABSTRACT: This project characterizes chamber-specific proteomic remodeling in a murine three-hit HFpEF model that develops right ventricular dysfunction, using chow, hypoxia alone, and HFD+L-NAME as control conditions. The three-hit model (hypoxia, high-fat diet, and L-NAME) recapitulates key features of human HFpEF, including left ventricular diastolic dysfunction and secondary right ventricular hypertrophy and dysfunction.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

DISEASE(S): Heart Failure

SUBMITTER: Pauline Fahjen  

LAB HEAD: Philipp Mertins

PROVIDER: PXD074772 | Pride | 2026-09-07

REPOSITORIES: Pride