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Cysteine Redox proteomics of PDIA6 over-expressing skeletal muscle

ABSTRACT: To investigate the role of PDIA6 on changes to specific cysteine residues with altered redox status and insulin senstivity, we overexpressed either GFP control or FLAG-PDIA6 throughout the musculature of 4-day old male C57BL/6J mice via intraperitoneal injection with MyoAAV (Fig. 5F). At 8 weeks of age, mice were placed on a HFD for 12 weeks to induce insulin resistance. Muscle lysates were were labelled with iodoTMT and analysed by LC-MS/MS

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skeletal Muscle

SUBMITTER: Benjamin Parker

LAB HEAD: Benjamin Parker

PROVIDER: PXD075204 | Pride | 2026-05-29

REPOSITORIES: Pride

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			Action	DRS
	251009_Astral2_BP-11920_A.msf	Msf
	251009_Astral2_BP-11920_A1.raw	Raw
	251009_Astral2_BP-11920_A10.raw	Raw
	251009_Astral2_BP-11920_A11.raw	Raw
	251009_Astral2_BP-11920_A12.raw	Raw

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