Proteomic identification of primate-specific lncRNA LINC01021 interactors via RNA pull-down MS

ABSTRACT: Long non-coding RNAs (lncRNAs) play critical regulatory roles in primate-specific biological processes, yet many primate-specific lncRNAs and their protein interactors remain poorly characterized. In this study, we focused on primate-specific lncRNAs as potential drivers of protein interactions. Using RNA affinity pull-down coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS), we identified proteins interacting with LINC01021 in primate-derived cells. Key findings include specific enrichment of RBMS proteins, suggesting a functional role in RNA metabolism or gene regulation. This dataset provides proteomic evidence for primate-specific lncRNA-protein interactions and contributes to understanding evolutionary adaptations in primates.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Embryonic Fibroblast, Cell Culture

DISEASE(S): Disease Free

SUBMITTER: Yan Zhang  

LAB HEAD: Yonghan He

PROVIDER: PXD075354 | Pride | 2026-06-29

REPOSITORIES: Pride