Glycan-based Biological Degraders Targeting the Cytokine Immune Axis

ABSTRACT: The project investigates targeted degradation of IL-6 and sIL6-R using bispecific Biological Degraders (BioDegs) that enable receptor-mediated uptake via the asialoglycoprotein receptor (ASGPR). Various IL-6(R)–binding scaffolds were modified with triantennary N-acetylgalactosamine (TGN) to promote lysosomal targeting. Mass spectrometry was used to determine the glycan-to-protein ratio after modification of the different binders, providing analytical characterization of the conjugates and confirming successful generation of BioDeg constructs.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Marcin Luzarowski  

LAB HEAD: Marcin Luzarowski

PROVIDER: PXD075514 | Pride | 2026-03-17

REPOSITORIES: Pride