Basal Proteomics of T-cell lymphoma cell cultures

ABSTRACT: This dataset contains shotgun LC-MS/MS proteomic data from 30 established T- and NK-cell-derived lymphoma cell cultures. These data were collected to quantify baseline protein abundance across in vitro models of peripheral T- and NK-cell lymphomas. In downstream analyses we identified correlations between variably expressed proteins and drug sensitivities to compounds commonly used in the treatment of hematologic malignancies. These analyses were integrated with results from pooled genome-wide CRISPR screens to identify proteins whose abundance correlates with drug response and whose perturbation alters lymphoma cell sensitivity to these therapies.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell, Cell Culture

DISEASE(S): Lymphoma

SUBMITTER: Angie Mordant  

LAB HEAD: Adam Palmer

PROVIDER: PXD075893 | Pride | 2026-09-07

REPOSITORIES: Pride