Persulfidome of A549 alveolar epithelial cells

ABSTRACT: To better define the relationship between persulfidation and the cellular antifungal response, we analyzed the cellular persulfidome (proteome of persulfidated proteins) in A549 and in CTH-/- cells upon challenge with Aspergillus fumigatus conidia and/or the sulfide donor GYY4137. All proteins were extracted, the persulfidated fraction was enriched using the dimedone-switch method following exposure to either 100 µM of GYY4137, A. fumigatus conidia (multiplicity of infection 1:10), both, or neither stimulus (±GYY4137, ±A. fumigatus), and the persulfidated proteins were identified by LC/MS

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

SUBMITTER: Jorge Amich  

LAB HEAD: Jorge Amich

PROVIDER: PXD076106 | Pride | 2026-08-17

REPOSITORIES: Pride