Systematic Analysis of Plasma-Derived Extracellular Vesicle-Enriched Samples in Age-Related Macular Degeneration Reveals Oxidative Stress Linked to Altered Lipid and Protein Profiles

ABSTRACT: Vision impairment caused by age-related macular degeneration (AMD) is a global health priority. Retinal pathology is driven by aging and exacerbated by genetic and environmental risk factors. Peripheral blood circulation is increasingly recognised as a contributor to disease initiation and progression, and a source of biomarkers to support earlier diagnosis and personalised treatment strategies. Here we performed an analysis of plasma-derived extracellular vesicle (EV)-enriched samples from 11 AMD and 11 controls. A proteomic analysis identified significantly changed proteins in AMD, many of which appeared downregulated with a strong interaction network including AMD-associated complement proteins and endopeptidase inhibitor activity. Importantly, many of the altered proteins were previously reported AMD biomarker candidates and involved in pathways known to influence AMD: oxidative stress response, immune system functioning and proteolysis dysregulation.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Age Related Macular Degeneration

SUBMITTER: Carina Hansohn  

LAB HEAD: Henning Urlaub

PROVIDER: PXD076119 | Pride | 2026-09-07

REPOSITORIES: Pride