Protein propionylation in Pcca deficiency

ABSTRACT: To determine the prevalence and identify any enrichment of lysine propionylation in PCC deficiency, an analysis comparing the propionylated liver proteins of control and liver-specific Pcca knockout mice was performed. Liver-specific knockout of PCC activity was induced in mice with floxed axons for the Pcca gene (Pcca ff) at 5 weeks of age using iCre-AAV with a TBG promoter. For controls, Pcca ff mice were injected with eGFP-AAV under the same promoter.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

DISEASE(S): Propionic Acidemia

SUBMITTER: Jasmine Encarnacion  

LAB HEAD: Michael J Wolfgang

PROVIDER: PXD076266 | Pride | 2026-04-09

REPOSITORIES: Pride