IWS1 stimulates transcription elongation

ABSTRACT: Transcription elongation requires the coordination of many factors, but the molecular role of these factors are not fully understood. We used cryo-electron microscopy and in vitro RNA extension assays to show that the histone chaperone IWS1 stimulates transcription using a series of short motifs in its C-terminus that contact separate components of the elongation machinery.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Della Syau  

LAB HEAD: Lucas Farnung

PROVIDER: PXD076498 | Pride | 2026-06-08

REPOSITORIES: Pride