Proteomics

Dataset Information

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Immmunopeptidomics data from reticulocytes of Plasmodium vivax infected human donors

ABSTRACT: Peripheral blood samples from 7 acute malaria patients with random HLA typing were analysed by immunopeptidomics. The donors were recruited in Porto Velho, Rondônia, a malaria endemic region in Brazil, were confirmed to be infected with Pv, and not Pf, with parasitemia ranging from 2-3 crosses (501-100,000 parasites/mm3). Highly purified Retics contained 4.3x107 to 7x108 cells, accounting for 98.11.2% of iRetics, 1.31.1% of uninfected RBCs, and 0.010.008% of nucleated cell contamination.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Reticulocyte, Blood

DISEASE(S): Plasmodium Vivax Malaria

SUBMITTER: Nicola Ternette  

LAB HEAD: Nicola Ternette

PROVIDER: PXD077321 | Pride | 2026-07-21

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
FL1029_IPP114_PB_CB_vivax_1_even.raw Raw
FL1029_IPP114_PB_CB_vivax_1_odd.raw Raw
FL1029_IPP114_PB_CB_vivax_2_even.raw Raw
FL1029_IPP114_PB_CB_vivax_2_odd.raw Raw
FL1029_IPP114_PB_CB_vivax_3_even.raw Raw
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Publications

Identification of cross-stage, cross-species malaria CD8<sup>+</sup> T cell antigens.

Barbosa Camila R R CRR   de Lacerda Luna B LB   Bettencourt Paulo J G PJG   Morrow David D   Pereira Dhelio B DB   Aleshnick Maya M   Mitchell Julie L JL   Poulton Nicholas C NC   Gomes Cristopher C   Cordeiro Lídia P B LPB   Doumbia Kadia K   Ntalla Christina C   Arama Charles C   Zhao Zezhou Z   Maia Guilherme C GC   Almeida Gregório G GG   Schrimpf Marie Rose MR   Hart Thalia F TF   Haumpy Derek D   Medeiros-Rodrigues Beatriz C BC   Costa Camila M CM   Nicastri Annalisa A   Gilbride Roxanne M RM   Schell John B JB   Kirtley Payton P   Antonelli Lis R V LRV   Gaiha Gaurav D GD   Hansen Scott G SG   Lieberman Judy J   Gazzinelli Ricardo T RT   Niangaly Moussa M   Woodford John J   Goldberg Joel J   Früh Klaus K   Portugal Silvia S   Duffy Patrick E PE   Ternette Nicola N   Wilder Brandon B   Hill Adrian V S AVS   Junqueira Caroline C  

Nature 20260701 8123

A major limitation on the development of a malaria vaccine is the lack of validated T cell epitope targets. Plasmodium falciparum is the most prevalent malaria parasite affecting humans in Africa, whereas Plasmodium vivax is more widespread and is the main species that causes malaria in the Americas and Asia<sup>1</sup>. P. vivax exclusively infects peripheral-blood reticulocytes, which retain RNA and the capacity for host protein synthesis<sup>2</sup>. We previously reported that reticulocytes  ...[more]

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