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TAOK3 controls naïve T cell homeostasis

ABSTRACT: Genetic deletion or kinase inactivation of TAOK3 resulted in a profound, cell-intrinsic loss of naive CD8⁺ T cells. Despite enhanced sensitivity to TCR ligation and enhanced downstream signalling, proliferating CD8⁺ T cells did not survive in vitro and anti-viral CD8⁺ T cell immunity was compromised in vivo in the absence of TAOK3. To delineate the molecular pathways governed by TAOK3, we performed an unbiased phosphoproteomic analysis of Taok3-deficient cells.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Spleen

SUBMITTER: Teresa Mendes Maia

LAB HEAD: Sahine Lameire

PROVIDER: PXD077760 | Pride | 2026-06-02

REPOSITORIES: Pride

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			Action	DRS
	PRC-6765MP_UPRC_10090X05914_2p_Ionopticks24_PM4_Lambrecht_PTM_SPR1.raw	Raw
	PRC-6765MP_UPRC_10090X05916_2p_Ionopticks24_PM4_Lambrecht_PTM_SPR2.raw	Raw
	PRC-6765MP_UPRC_10090X05918_2p_Ionopticks24_PM4_Lambrecht_PTM_SPR3.raw	Raw
	PRC-6765MP_UPRC_10090X05920_2p_Ionopticks24_PM4_Lambrecht_PTM_SPR4.raw	Raw
	PRC-6765MP_UPRC_10090X05922_2p_Ionopticks24_PM4_Lambrecht_PTM_SPR5.raw	Raw

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