Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Proteomic profiling of AML patient-derived xenografts across serial transplantation

ABSTRACT: This dataset contains mass spectrometry-based proteomic profiling of acute myeloid leukemia patient-derived xenograft samples collected across serial transplantation stages. The study aimed to characterize proteome remodeling associated with leukemia propagation and disease evolution in AML PDX models. Proteomic data were generated from xenografted human AML cells and are part of a broader multi-omics study integrating serial xenotransplantation, transcriptomics, proteomics and functional therapeutic analyses.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Leukocyte, Bone Marrow, Blood

DISEASE(S): Acute Leukemia

SUBMITTER: jerome Tamburini

LAB HEAD: Jerome Tamburini

PROVIDER: PXD078079 | Pride | 2026-07-20

REPOSITORIES: Pride

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	20241206_LU50HMC14_pl24087_JT_08.raw	Raw
	20241206_LU50HMC15_pl24087_JT_15.raw	Raw
	20241206_LU50HMC16_pl24087_JT_12.raw	Raw
	20241206_LU50HMC17_pl24087_JT_10.raw	Raw
	20241206_LU50HMC19_pl24087_JT_05.raw	Raw

Items per page:

1 - 5 of 23

Similar Datasets

Single-cell RNA-seq profiling of AML patient-derived xenografts across serial transplantation

Project description:Single-cell RNA sequencing was performed on AML PDX samples across serial transplantation (P0, P1, P2) to investigate transcriptional evolution and leukemic stem cell dynamics.

2026-07-20 | GSE329946 | GEO

Translational remodeling across serial xenotransplantation in acute myeloid leukemia patient-derived xenografts

Project description:Translational remodeling across serial xenotransplantation in acute myeloid leukemia patient-derived xenografts

| PRJNA1462680 | ENA

DNA methylation remodeling across serial xenotransplantation in acute myeloid leukemia patient-derived xenografts

Project description:DNA methylation remodeling across serial xenotransplantation in acute myeloid leukemia patient-derived xenografts

| PRJNA1462679 | ENA

Translational remodeling across serial xenotransplantation in acute myeloid leukemia patient-derived xenografts

Project description:We performed ribosome profiling (Ribo-seq) on acute myeloid leukemia patient-derived xenograft models across serial transplantation passages to characterize translational remodeling associated with leukemia propagation.

2026-07-20 | GSE330064 | GEO

Single-cell RNA-seq profiling of AML patient-derived xenografts across serial transplantation

Project description:Single-cell RNA-seq profiling of AML patient-derived xenografts across serial transplantation

| PRJNA1462256 | ENA

DNA methylation remodeling across serial xenotransplantation in acute myeloid leukemia patient-derived xenografts

Project description:We performed Illumina Infinium MethylationEPIC array profiling of acute myeloid leukemia patient-derived xenograft models across serial transplantation passages P0, P1, and P2 to characterize DNA methylation changes associated with leukemia propagation.

2026-07-20 | GSE330065 | GEO

Gene expression profiles of newly generated MLL-AF9 leukemia cells and aggressive MLL-AF9 leukemia cells generated through serial transplantations.

Project description:Immunogenicity of acute myeloid leukemia (AML) keeps changing during tumor evolution, showing a trend that the aggressive AMLs generate through serial transplantations are susceptible to NK cell-mediated tumor suppression. To access molecular differences between the newly developed AML cells and aggressive AML cells generated through serial transplantations, we performed RNA-seq using newly generated mouse AML cells trasduced with MLL-AF9, and the aggressive MLL-AF9 cells obtained after 5 times serial transplantations in the non-irradiated recipient mice.

2023-12-27 | GSE245358 | GEO

Evolution of leukemic stem cell states and transcriptional programs across serial xenotransplantation in acute myeloid leukemia

Project description:We performed bulk RNA-seq profiling of acute myeloid leukemia (AML) patient-derived xenograft models across serial transplantation passages (P0, P1, P2) to characterize transcriptional changes associated with leukemia propagation and stem cell activity.

2026-07-20 | GSE329505 | GEO

Serial xenotransplantation in NSG mice promotes a hybrid epithelial/mesenchymal gene expression signature and stemness in rhabdomyosarcoma cells

Project description:NSTS-11 cell line derived from a primary embryonal rhabdomyosarcoma was used for serial xenotransplantation in NSG mice in vivo. Subsequently, three cell lines, LTB1, LTB5, and LTB24, were derived from primary, secondary, and tertiary xenograft tumors, respectively. Gene expression profiling of all four cell lines was performed to identify changes in gene expression over the course of serial xenotransplantation, which was associated with a gradual increase of stemness of embryonal rhabdomyosarcoma cells. For each of the xenograft-derived cell lines, the parental NSTS-11 cell line served as a reference control.

2019-04-30 | E-MTAB-7664 | biostudies-arrayexpress

Genotyping analysis of AML samples at diagnosis and relapse after Hematopoietic Stem Cell Transplantation (HSCT)

Project description:Genotype profiling of Acute Myeloid Leukemia samples. This dataset includes patients with diagnosis of de novo or secondary AML who experienced non-HLA loss disease relapse after allo-HCT, and for whom paired pre- and post-transplant viable leukemic samples were available.

2019-01-30 | E-MTAB-7631 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data