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Mouse heart in vivo BioID masspec data

ABSTRACT: Diastolic dysfunction, defined by increased ventricular stiffness, is a common pathological feature across diverse forms of heart disease and a major contributor to clinical syndromes such as heart failure with preserved ejection fraction. However, the cardiomyocyte-intrinsic mechanisms that lead to diastolic dysfunction remain incompletely understood. We found SORBS2 as a cardiomyocyte-intrinsic regulator of diastolic function. To reveal the underlying mechanism, we used proximity proteomics in intact, living hearts to identify proteins enriched near SORBS2.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Fujian Lu

LAB HEAD: William T. Pu

PROVIDER: PXD078837 | Pride | 2026-05-26

REPOSITORIES: Pride

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			Action	DRS
	106479_113931.mzid	Mzid
	106480_113932.mzid	Mzid
	106481_113933.mzid	Mzid
	106482_113934.mzid	Mzid
	106483_113935.mzid	Mzid

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