From stem cells to somites: revealing genetic and exogenous factors of human embryogenesis

ABSTRACT: In this project, we characterized the temporal dynamics of protein expression during the differentiation of human iPSCs to somitoids, stem cell–derived 3D models that recapitulate early embryonic somitogenesis. Using quantitative time-course proteomics, we captured how protein abundance changed as pluripotent stem cells progressed into segmented, organized structures, providing insight into the molecular processes underlying human axial development.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell, Hipsc Cell

DISEASE(S): Disease Free

SUBMITTER: S Stelloo  

LAB HEAD: Suzan Stelloo

PROVIDER: PXD079129 | Pride | 2026-08-07

REPOSITORIES: Pride