Tau-P301L transgenic cynomolgus monkey cortex and spinal cord 4D label-free proteome dataset

ABSTRACT: This dataset contains 4D-label-free quantitative proteomic profiles of cortex and spinal cord tissues from Tau P301L transgenic cynomolgus monkeys and wild-type controls. Sixteen tissue samples were analyzed, including wild-type cortex, wild-type spinal cord, Tau P301L cortex, and Tau P301L spinal cord, with four biological samples in each group. Peptides were measured on a Bruker timsTOF Pro mass spectrometer coupled to a nanoElute LC system using PASEF acquisition. Raw Bruker data were searched and quantified with MaxQuant 1.6.14 against the UniProt Macaca fascicularis protein database uniprot_Macaca_fascicularis_80185_20230915.fasta. The experiment identified 6,632 proteins and quantified 6,310 proteins, providing a tissue-resolved proteomic resource for the Tau P301L non-human-primate model.The deposited dataset includes raw Bruker .d files, MaxQuant search outputs and processed protein quantification matrices.

INSTRUMENT(S):

ORGANISM(S): Macaca Fascicularis (crab-eating Macaque) (cynomolgus Monkey)

TISSUE(S): Brain, Spinal Cord, Cerebral Cortex

DISEASE(S): Tauopathy

SUBMITTER: Weien liang  

LAB HEAD: Zhuchi Tu

PROVIDER: PXD079349 | Pride | 2026-08-20

REPOSITORIES: Pride