Whole-proteome profiling of human lung cancer brain metastasis-associated fibroblasts
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain, Primary Cell, Cell Culture, Fibroblast
DISEASE(S): Lung Cancer,Brain Cancer
SUBMITTER: 
Jakub Cervenka
LAB HEAD: Helena Kupcová Skalníková
PROVIDER: PXD080067 | Pride | 2026-08-03
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 2024_Human_cont_iRT.fasta | Fasta | |||
| 20251023_215728_CAF_vs_wt_cells.sne | Other | |||
| ProteinGroups_Quantity_Report.xlsx | Xlsx | |||
| Raw_data.zip | Other | |||
| checksum.txt | Txt |
Items per page: 5 1 - 5 of 5 |
Publications
Brain metastasis-associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion.
Výmolová Barbora B Pfeiferová Lucie L Smetana Tadeáš Karel TK Výmola Petr P Ternerová Nikola N Zubaľ Michal M Kolář Michal M Šáchová Jana J Gyönyörová Soňa S Balážiová Eva E Houdová Megová Magdalena M Červenka Jakub J Kupcová Skalníková Helena H Španko Michal M Smetana Karel K Lacina Lukáš L Netuka David D Tomáš Robert R Bušek Petr P Šedo Aleksi A
Brain pathology (Zurich, Switzerland) 20260804
Brain metastases (BrM) are a frequent and life-threatening complication of solid tumours, with lung cancer representing their most common source. While cancer-associated fibroblasts (CAFs) are well-established contributors to tumour progression in many extracranial malignancies, their presence and function within the brain tumour microenvironment, where fibroblasts have long been considered scarce or absent, remain poorly understood. Here, we isolated and characterised fibroblast-like cells from ...[more]
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