Proteomics

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Human gastric extracellular matrix hydrogels maintain organoid growth and reduce gene expression associated with stemness and inflammation


ABSTRACT: Human gastric organoids (HGOs) are 3-D cultures of primary gastric epithelial cells that serve as in vitro models for gastric epithelial physiology, development, and disease. The extracellular matrix material that organoids are maintained in provides crucial signals to the epithelial cells, regulating their function and growth. We here describe the application of human gastric ECM (hgECM) for HGO cultures, to provide a tissue- and species-specific growth matrix.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Gastric Mucosa

SUBMITTER: Michelle Cherne  

LAB HEAD: Diane Bimczok, DVM, PhD

PROVIDER: PXD081816 | Pride | 2026-07-29

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
2023_01_UniProt_Homo_sapiens.fasta Fasta
2026_01_UniProt_Homo_sapiens.fasta Fasta
BimczokD_022323_01.raw Raw
BimczokD_022323_02.raw Raw
BimczokD_022323_SampleList.csv Csv
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