Cardiac amyloidosis typing by S-Trap-based protocol and intensity-based diagnostic algorithm

ABSTRACT: Proposal of an S-Trap-based proteomics workflow for amyloid typing of EMBs coupled with a scoring algorithm based on protein intensities.The protocol and the algorithm have been validated by the comparison of MS-based diagnosis with immunohistochemistry diagnosis and patient clinical data. The study was conducted on 28 patients with a clinical diagnosis of CA and either an inconclusive IHC response or an atypical disease phenotype, that were selected for additional proteomics-based investigation.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart

SUBMITTER: Francesco Greco  

LAB HEAD: Liam A. McDonnell

PROVIDER: PXD082501 | Pride | 2026-08-18

REPOSITORIES: Pride