Early fallopian tube lesions and HGSC spatial proteomics dataset

ABSTRACT: High-grade serous carcinoma (HGSC) is the most common ovarian cancer subtype, typically diagnosed at late stages with poor prognosis. Understanding early molecular events driving HGSC progression is crucial for early-stage cancer detection and development of effective treatment stategies. We performed and integrated spatial cell-type resolved proteomics and paired transcriptomics across 25 women with precursor lesions of the fallopian tube and/or HGSC. Epithelial cell signatures revealed early activation of SUMOylation machinery, increased ATR and Wnt signaling, and enhanced MHC-I antigen presentation along the disease trajectory. The stroma exhibited extracellular matrix (ECM) remodeling and interferon-mediated inflammation. Serous tubal intraepithelial carcinomas (STICs) in cancer patients contained a pro-coagulative signature and reduced APOA1/2 compared to STICs in individuals without cancer. Functional studies confirmed the role of epithelial-derived TRIP13 and SUMOylation, and cancer-associated fibroblast-derived SULF1 and BGN in HGSC progression. These findings provide unique molecular insights into HGSC pathogenesis and identify potential new therapeutic targets for intervention.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Female Reproductive System, Epithelial Cell, Stromal Cell

DISEASE(S): Malignant Neoplasm Of Ovary

SUBMITTER: Andreas Metousis  

LAB HEAD: Prof. Dr. Matthias Mann

PROVIDER: PXD084823 | Pride | 2026-09-29

REPOSITORIES: Pride