DIA Proteomic Profiling of Mouse Lung Tissues Reveals the Antifibrotic Effects of Osmundacetone in Bleomycin-Induced Pulmonary Fibrosis

ABSTRACT: This study investigated the antifibrotic effects of osmundacetone (OSMA) in a bleomycin-induced mouse model of pulmonary fibrosis. Data-independent acquisition (DIA)-based quantitative proteomics was performed to characterize protein expression changes in mouse lung tissues from control, pulmonary fibrosis model, and OSMA-treated groups. Proteomic profiling revealed significant alterations in proteins associated with extracellular matrix organization, collagen metabolism, inflammatory responses, and metabolic regulation. OSMA treatment partially reversed fibrosis-associated proteomic changes, providing molecular evidence supporting its therapeutic potential against pulmonary fibrosis.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

DISEASE(S): Pulmonary Fibrosis

SUBMITTER: Zewen Wang  

LAB HEAD: Yanling Zhang

PROVIDER: PXD085814 | Pride | 2026-10-19

REPOSITORIES: Pride