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Acinetobacter variabilis

ABSTRACT: Emergence of multidrug-resistant Acinetobacter variabilis in Japan

PROVIDER: PRJDB10565 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	DRR244674_1.fastq.gz	Fastqsanger.gz
	DRR244674_2.fastq.gz	Fastqsanger.gz
	DRR244675_1.fastq.gz	Fastqsanger.gz

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Acinetobacter variabilis

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Project description:Asymptomatic gut colonization increases the risk of clinical infection and transmission by the multidrug-resistant pathogen Acinetobacter baumannii. Ornithine utilization was shown to be critical for A. baumannii competition with the resident microbiota to persist in gut colonization, but the regulatory mechanisms and cues are unknown. Here, we identify a transcriptional regulator, AstR, that specifically activates the expression of the A. baumannii ornithine utilization operon astNOP. Phylogenetic analysis suggests that AstR was co-opted from the Acinetobacter arginine utilization ast(G)CADBE locus and is specialized to regulate ornithine utilization in A. baumannii. Reporter assays showed that astN promoter expression was activated by ornithine but inhibited by glutamate and other preferred amino acids. astN promoter expression was similarly activated by incubation with fecal samples from conventional mice but not germ-free mice, suggesting AstR-dependent activation of the astN promoter responds to intermicrobial competition for amino acids. Finally, AstR was required for A. baumannii to colonize the gut in a mouse model. Together, these results suggest that pathogenic Acinetobacter species evolved AstR to regulate ornithine catabolism, which is required to compete with the microbiota during gut colonization.

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2015-10-27 | PXD002033 | Pride

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