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Staphylococcus aureus

ABSTRACT: CA-MRSA surveillance with MML in Japan

PROVIDER: PRJDB11169 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR273469_1.fastq.gz	Fastqsanger.gz
	DRR273469_2.fastq.gz	Fastqsanger.gz
	DRR273470_1.fastq.gz	Fastqsanger.gz
	DRR273470_2.fastq.gz	Fastqsanger.gz
	DRR273471_1.fastq.gz	Fastqsanger.gz

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Staphylococcus aureus

Project description:CA-MRSA surveillance with MML in Japan

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Project description:Staphylococcus aureus can cause a broad spectrum of diseases that vary widely in clinical presentation and disease severity[121]. Methicillin-Resistant S. aureus (MRSA) strains first described in the 1960’s[122] were hospital acquired (HA MRSA), however in the 1990’s, community-associated MRSA strains (CA MRSA) were identified and are considered to be more virulent[16]. Therapeutics and management of MRSA focuses on novel antibacterials and vaccines targeting virulence factors. To date no clinical trials for vaccines have succeeded[123] due to the poor understanding of the pathogenic mechanisms exhibited by S.aureus.We investigated the differential gene expression of four clinical MRSA strains in vitro, belonging to HA and CA MRSA, at the stationary and exponential growth phases, using RNA-seq on the Ion torrent next generation sequencing platform. This study reveals the high diversity of virulence trait expression among MRSA strains within strains as well as between different growth phases, and also suggests potential factors other than PVL that contributes to enhanced virulence in CA MRSA

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