Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human skin metagenome

ABSTRACT: Microenvironment-specific skin microbiome

PROVIDER: PRJDB15341 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	DRR446609_1.fastq.gz	Fastqsanger.gz
	DRR446609_2.fastq.gz	Fastqsanger.gz
	DRR446610_1.fastq.gz	Fastqsanger.gz
	DRR446610_2.fastq.gz	Fastqsanger.gz
	DRR446611_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

human skin metagenome

Project description:UCSD Skin Microbiome Project

| PRJDB716 | ENA

human skin metagenome

Project description:Human Skin Microbiome Metagenome

| PRJNA277905 | ENA

human skin metagenome

Project description:UCSD-Colgate Skin microbiome project

| PRJDB4881 | ENA

human skin metagenome

Project description:The Human Skin Microbiome in Acne

| PRJDB10875 | ENA

human skin metagenome

Project description:Skin microbiome by different collection methods

| PRJDB5459 | ENA

human skin metagenome

Project description:Skin microbiome associated with atopic dermatitis

| PRJNA268694 | ENA

Human Skin Metagenome Associated with Acne

Project description:<p>Studies have emphasized the importance of disease-associated microorganisms in perturbed communities, however, the protective roles of commensals are largely under recognized and poorly understood. Using acne as a model disease, we investigated the determinants of the overall virulence property of the skin microbiota when disease- and health-associated organisms coexist in the community. By ultra-deep metagenomic shotgun sequencing, we revealed higher relative abundances of propionibacteria and Propionibacterium acnes phage in healthy skin. In acne patients, the microbiome composition at the species level and at P. acnes strain level was more diverse than in healthy individuals, with enriched virulence-associated factors and reduced abundance of metabolic synthesis genes. Based on the abundance profiles of the metagenomic elements, we constructed a quantitative prediction model, which classified the clinical states of the host skin with high accuracy in both our study cohort (85%) and an independent sample set (86%). Our results suggest that the balance between metagenomic elements, not the mere presence of disease-associated strains, shapes the overall virulence property of the skin microbiota. This study provides new insights into the microbial mechanism of acne pathogenesis and suggests probiotic and phage therapies as potential acne treatments to modulate the skin microbiota and to maintain skin health.</p>

| phs001655 | dbGaP

human skin metagenome

Project description:The skin microbiome of DOCK8-deficient patients

| PRJNA471898 | ENA

human skin metagenome

Project description:Skin microbiome of six healthy Japanese adults.

| PRJDB15042 | ENA

human skin metagenome

Project description:Antimicrobial function of skin microbiome in atopic dermatitis

| PRJDB5347 | ENA