Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: The functional analysis of ladinin-1 in oral squamous cell carcioma cell lines.

PROVIDER: PRJDB16201 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	DRR493440_1.fastq.gz	Fastqsanger.gz
	DRR493440_2.fastq.gz	Fastqsanger.gz
	DRR493441_1.fastq.gz	Fastqsanger.gz
	DRR493441_2.fastq.gz	Fastqsanger.gz
	DRR493442_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Homo sapiens

Project description:Gene expression analysis of human oral squamous cell carcinoma cell lines (HSC-4, OSC19)

| PRJNA177223 | ENA

Homo sapiens foetal mesenchymal stem cell miRNA transcriptome

Project description:We have sequenced miRNA libraries from human embryonic, neural and foetal mesenchymal stem cells. We report that the majority of miRNA genes encode mature isomers that vary in size by one or more bases at the 3’ and/or 5’ end of the miRNA. Northern blotting for individual miRNAs showed that the proportions of isomiRs expressed by a single miRNA gene often differ between cell and tissue types. IsomiRs were readily co-immunoprecipitated with Argonaute proteins in vivo and were active in luciferase assays, indicating that they are functional. Bioinformatics analysis predicts substantial differences in targeting between miRNAs with minor 5’ differences and in support of this we report that a 5’ isomiR-9-1 gained the ability to inhibit the expression of DNMT3B and NCAM2 but lost the ability to inhibit CDH1 in vitro. This result was confirmed by the use of isomiR-specific sponges. Our analysis of the miRGator database indicates that a small percentage of human miRNA genes express isomiRs as the dominant transcript in certain cell types and analysis of miRBase shows that 5’ isomiRs have replaced canonical miRNAs many times during evolution. This strongly indicates that isomiRs are of functional importance and have contributed to the evolution of miRNA genes

2014-08-06 | GSE58734 | GEO

Homo sapiens

Project description:Expression data from oral squamous cell carcinoma (OSCC)-derived cell lines and normal oral keratinocytes

| PRJNA145085 | ENA

Homo sapiens

Project description:Array CGH analysis of Oral Squamous Cell Carcinoma

| PRJNA130641 | ENA

Homo sapiens

Project description:Oral dysplasias and oral squamous cell carcinoma

| PRJNA102765 | ENA

Homo sapiens

Project description:Gene expression profiles in human oral squamous cell carcinoma tissues and cell lines