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Homo sapiens

ABSTRACT: RNA sequencing and analysis of human eosinophils stimulated with all-trans retinoic acid and IL-5

PROVIDER: PRJDB18171 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	DRR568691.fastq.gz	Fastqsanger.gz
	DRR568696.fastq.gz	Fastqsanger.gz
	DRR568697.fastq.gz	Fastqsanger.gz
	DRR568699.fastq.gz	Fastqsanger.gz

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Proteomic analysis of human eosinophils stimulated with all-trans retinoic acid and IL-5

Project description:Activated eosinophils is a major cell type to be involved in allergic diseases. IL-5 primarily activates eosinophils and prolongs their survival. In contrast, all-trans retinoic acid has regulatory effects in the immune system. The aim of this study is to clarify the role of all-trans retinoic acid in the regulation of human eosinophils.

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Effect of retinoic acid on gene expression in CD4 cells stimulated with anti CD3 and CD28

Project description:RNA extracted from CD4 cells was analyzed using affymetrix gene array chips.Data set includes analysis of RNA from DMSO or ATRA treated samples. ATRA induced the expression of a number of genes including LZTFL1. Retinoic acids, which are metabolites of vitamin A, have been shown to be involved in multiple T cell effector responses through their binding to the retinoic acid receptor, a ligand-activated transcription factor. Because the molecular mechanism of regulation by retinoic acid is still not fully uncovered, we investigated the gene expression profile of all-trans retinoic acid (ATRA)-treated human CD4(+) T cells. Leucine zipper transcription factor-like 1 (LZTFL1) was upregulated by ATRA in a dose- and time-dependent manner. The expression of LZTFL1 depended on both ATRA and TCR signaling. LZTFL1 accumulated in the plasma membrane compartment of human CD4(+) T cells, and, during immunological synapse formation, it transiently redistributed to the T cell and APC contact zone, indicating its role in T cell activation. Live-cell imaging demonstrates that at the initial stage of immunological synapse formation, LZTFL1 is concentrated at the APC contact site, and, during later stages, it relocates to the distal pole. Knockdown of LZTFL1 reduced the basal- and ATRA-induced levels of IL-5 in CD4(+) T cells, and overexpression of LZTFL1 enhanced the TCR-mediated NFAT signaling, suggesting that LZTFL1 is an important regulator of ATRA-induced T cell response. Together, these data indicate that LZTFL1 modulates T cell activation and IL-5 levels. CD4 cells were isolated from human PBMCs and primed with anti-CD3 and IL-2 in presence and absence of retinoic acid. Two days later RNA was extracted and analyzed.

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